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What is Alzheimer’s Disease?
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Most prevalent form of dementia, accounting for approximately 60-70% of all dementia cases.
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Primary pathologies include:
- Amyloid-β (Aβ) plaques (abnormal protein accumulation in the brain)
- Hyperphosphorylated Tau (pTau) (formation of neurofibrillary tangles)
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These pathological changes lead to neuronal degeneration, synaptic loss, ultimately brain atrophy.
Early Detection enables Early Intervention
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Amyloid-β (Aβ) accumulates in the brain of people with Alzheimer’s Disease 15 to 20 years before clinical symptoms
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The accumulation co-occurs with cerebral and blood biomarker abnormalities
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Existing Alzheimer’s medications are most effective at early stage
Who is At Risk?
1. Person aged 50 or above.
2. Person with family history of dementia.
3. Person with high AD risk factors (stroke, 3 highs).
4. Person with suspicious cognitive decline behaviors.
Symptoms
Memory Decline
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Difficulties in Expression
Disorientation
in Time and Place
Emotional
Disturbances
